Mission Possible looks back on the story of Premrose Joven and her sacrifices for her children and husband, who are suffering from osteogenesis imperfecta. After being featured, the family of Premrose are now able to join more bazaars to earn more money for her children's education. The program then seeks the help of the DTI's Design Center Philippines to improve the designs of the beaded roses and cards that the Joven family creates. It also helps in choosing a brand name, registering the business, and creating a logo for the family's products. The Jovens also receive kind messages and help from various people, including St. Luke's Medical Center’s orthopedic surgeon Dr. Billardo del Rosario, who was referred by one of the program’s viewers.