Diether Ocampo was launched as a member of the Star Circle Batch II in 1995, and won his first stint on the big screen in the movie adaptation of the 90s television gag show Ang TV. He has then became one of ABS-CBN’s most bankable talents and given the opportunity to appear in major shows such as the Sunday variety show ASAP, the youth-oriented romantic drama series Gimik, the weekly gag show Super Laff-In, the weekly mystery drama Oka Tokat, the coming-of-age friendship drama Buttercup and Bora: Sons of The Beach--his sit-com with fellow Hunks Piolo Pascual, Jericho Rosales, Bernard Palanca and Carlos Agassi.
But Diether shone brightest in primetime drama series. He was part of at least 11 teleseryes, which is more than any actor has done in Philippine television. This includes Mula Sa Puso, Saan ka Man Naroroon, Recuerdo de Amor, Sana’y Wala Nang Wakas, Marina, ‘Til Death Do Us Part, Ikaw Ang Lahat Sa Akin, Rounin, Margarita, Princess Sarah, Lobo, Iisa Pa Lamang, Only You, Rubi, Sabel, Guns and Roses and Apoy Sa Dagat.
He was also able to showcase his versatility as an actor by delivering full dramatic performances in Calvento Files: The Movie, Dahil Mahal na Mahal Kita, Mula Sa Puso: The Movie, Soltera, Bukas Na Lang Kita Mamahalin, La Vida Rosa, and Sa’Yo Lamang; heartrob charms in Gimik:The Reunion, Jologs, Bcuz of U, , and 24/7 In Love; comedic stunts in Mamarazzi and Volta; and suspense-filled performances in Dalaw, Magandang Hatinggabi and Nasaan Ka Man.