Dra. Margaret Divinagracia (Coney Reyes) is considered the best heart surgeon in the country. With all the success she has gotten, Margaret holds herself in high regard. But everything changes as she meets Heart (Nayomi Ramos), who is the source of strength and happiness of her parents Jude (Zanjoe Marudo) and Clara (Bela Padilla). Living as one happy family, Heart, Jude, and Clara face each of life’s struggles together. However, their hopes are destroyed when Heart gets diagnosed with congenital heart disease. Desperate to find a cure for their daughter’s illness, they turn to Dra. Divinagracia, who faces what she considers her biggest failure yet – her inability to cure Heart’s illness. Their lives get even more complicated because while Heart hovers between life and death, her soul travels out of her body, with only Margaret being able to see and speak to her. Will Heart be saved from her condition? With Heart’s life in danger, what changes are bound to happen to her family? Will Heart be the one person who can change Margaret?