This natural comic first made waves as a housemate in Pinoy Big Brother: Double Up, where she eventually emerged as the Big Winner. With romance budding between her and fellow housemate Jason Francisco, they were immediately tapped to lead PBB’s first reality spin off Melason In Love. Having earned a good showbiz standing in a very short time, Melai was soon asked to play lead roles in the Precious Hearts Romances series Impostor and Mana Po. She then joined the cast of the fantaserye Kokey @ Ako and the gag show Banana Sundae and snagged the title role in the movie The Adventures of Pureza: Queen of the Riles. Her comic skills also made Melai a bankable television host, earning her stints in the short-lived noontime variety show Happy Yipee Yehey!, the celebrity reality challenge I Dare You: The Kapamilya Challenge, the morning show Umagang Kay Ganda and the impersonation competition Your Face Sounds Familiar, wherein she also won as grand champion during the first season. Melai has recently finished her daytime soap with Pokwang, entitled I Will Survive. She is currently seen hosting the daily talk show Magandang Buhay with fellow Your Face alumni Karla Estrada and Jolina Magdangal.